Amyloidosis | Definition , Etiology , Clinical features

September 18, 2011 | By | Reply More

Amyloidosis | Definition , Etiology , Clinical features

Amyloidosis Definition

•Amyloidosis is a rare metabolic disorder characterized by an abnormal extracellular deposition of amyloid, a fibrillar proteinaceous material, in tissues.
Etiology
•The etiology is not fully understood.
Picture2 Amyloidosis | ppt
Primary systemic amyloidosis: hemorrhagic bulla on the tongue.
Picture3 Amyloidosis | ppt
Primary systemic amyloidosis: deep red nodules on the lips
Picture4 Amyloidosis | ppt
Primary systemic amyloidosis: macroglossia, ecchymoses, and ulcer on the
tongue.
Clinical features
•Four major forms are recognized: primary, secondary, senile, and familial.
•Primary and secondary amyloidosis may be either systemic or localized.
•The primary systemic form is the most serious formof the disease, affecting individuals older than 50 years.
•Oral lesions are common, and present as multiple deep red tumors, with petechiae, ecchymoses, macroglossia, ulcers, bullae, salivary gland infiltration, and xerostomia (Figs ).
Skin (purpura, petechiae, papules, nodules, bullae, alopecia) and systemic disorders are common. In 10–25% of cases, the disease is associated with multiple myeloma.

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Category: Oral Medicine, Oral Pathology

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