Causes of Cell Injury

May 27, 2012 | By | Reply More

Causes of Cell Injury

These are :

  • Oxygen Deprivation
  • Physical Agents
  • Chemical Agents and Drugs
  • Infectious Agents
  • Immunologic Reactions
  • Genetic Derangements
  • Nutritional Imbalances
Oxygen Deprivation
  • Hypoxia – deficiency of oxygen
  • Ischemia – loss of blood supply (arterial flow or reduced venous drainage)
Physical Agents
  • Mechanical trauma
  • Extremes of temperature – burns, deep cold
  • Radiation
  • Electric shock
Chemical Agents and Drugs
  • Hypertonic concentration of salt – deranging electrolyte homeostasis
  • Poisons – arsenic, cyanide, or mercuric salts
  • Insecticides and Herbicides
  • Air pollutant – carbon monoxide
  • Occupational hazard – asbestos
  • Alcohol and Narcotic drugs
Infectious Agents
  • Parasites
  • Fungi
  • Bacteria
  • Rickettsiae
  • Viruses
Immunologic Reactions
  • Anaphylactic reaction to foreign protein or drug
  • Reactions to endogenous self-antigens – autoimmune diseases

Genetics Derangements

  • Congenital malformation – Down syndrome
  • Decreased life of red blood cell – Thalassemia, Sickle cell anemia
  • Inborn errors of metabolism

Nutritional Imbalances

  • Protein-calorie deficiencies
  • Vitamin deficiencies
  • Anorexia nervosa
  • Excesses of lipids – Obesity, Atherosclerosis
  • Metabolic diseases – Diabetes

Tags:

Category: Pathology

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