Cherubism : Etiology , Clinical features & Management
Cherubism is a genetic chromosomal disorder that is characterized by multiple multilocular bone lesions in the mandible and maxilla that starts in childhood, enlarge and then regress.
It is caused by 1 of several mutations in the SH3DP2 gene.
1. Common in male
2. Onset is between 6 months-7 years
3. Regress after puberty
4. Typically symmetrical swelling in the region of the angle of the mandible
5.In severe case, in the maxilla
6. The mandibular swelling may sometimes be so gross lingually as to interfere with speech, swallowing or even breathing
Occlusal feature: Teeth are frequently displaced even loosened
Radiograph: The lesion simulate multilocular cyst as a result of fine bony septa extending between soft tissue mass
1. As natural regression takes place, treatment is usually avoided
2. If disfigurement is severe, curettage or to pairing down of excessive tissue but recurrence occurs