Crohn Disease: Definition, Etiology , Clinical features, Differential diagnosis, Treatment

September 20, 2011 | By | Reply More

Crohn Disease: Definition, Etiology , Clinical features, Differential diagnosis, Treatment

Definition: Crohn disease or regional ileitis is a chronic inflammatory disease that primarily affects the ileum and other parts of the gastrointestinal tract.

Etiology: Unknown; probably immunologically mediated.

 

Clinical features:

  • The disease usually affects young individuals
  • presents clinically with abdominal pain, nausea, diarrhea, weight loss, low-grade fever, and rectal bleeding.
  • Extra-abdominal involvement includes arthritis, spondylitis, uveitis, and oral manifestations.
  • Oral lesions occur in 10–20% of patients and are characterized by nodular swelling, which may be ulcerated. Diffuse raised nodules resulting in a cobblestone appearance of the mucosa or mucosal tag lesions may occur.
  • Granulomatous lip swelling, angular cheilitis, gingival swelling, and atypical ulcerations may be seen.

Laboratory tests : Histopathological examination.

Differential diagnosis :

  • Orofacial granulomatosis,
  • epulis fissuratum,
  • pyogenic granuloma.

Treatment:

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Category: Dental, Oral Medicine, Oral Pathology

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