Crohn Disease: Definition, Etiology , Clinical features, Differential diagnosis, Treatment
Definition: Crohn disease or regional ileitis is a chronic inflammatory disease that primarily affects the ileum and other parts of the gastrointestinal tract.
Etiology: Unknown; probably immunologically mediated.
- The disease usually affects young individuals
- presents clinically with abdominal pain, nausea, diarrhea, weight loss, low-grade fever, and rectal bleeding.
- Extra-abdominal involvement includes arthritis, spondylitis, uveitis, and oral manifestations.
- Oral lesions occur in 10–20% of patients and are characterized by nodular swelling, which may be ulcerated. Diffuse raised nodules resulting in a cobblestone appearance of the mucosa or mucosal tag lesions may occur.
- Granulomatous lip swelling, angular cheilitis, gingival swelling, and atypical ulcerations may be seen.
Laboratory tests : Histopathological examination.
Differential diagnosis :
- Orofacial granulomatosis,
- epulis fissuratum,
- pyogenic granuloma.