Disseminated Intravascular Coagulation (DIC) : what and why occurs??

September 2, 2011 | By | Reply More

Disseminated Intravascular Coagulation (DIC) : what and why occurs??

Synonyms: Consumption coagulopathy, Defibrination syndrome.


  • DIC is a thrombotic disorder that ends up as a bleeding disorder.
  • Activation of the coagulation system with widespread fibrin formation and deposition.
  • Inappropriate release of tissue factor into the circulation.
  • Consumption of platelets, fibrinogen and factors II, V, VIII and XIII.
  • It is haemolytic and haemorrhagic anaemia.
  • Red cell fragmentation and intravascular haemolysis occur.

Causes/etiology of DIC: 

1.Obstetric and gynaecological problems

–        IUD

–        Retained dead fetus

–        Placental abruption

–        Amniotic fluid embolism

–        Septic abortion

2.Crush injuries

–        Release of massive amounts of tissue factor into the circulation

3.Tissue damage

–        Burns

–        Surgery or trauma

4.Haemolytic transfusion reactions


–        Gram negative septicaemia

–        Clostridium welchii septicaemia

–        Severe falciparum malaria (blackwater fever)

6. Malignancy

–        Widespread mucin-secreting adenocarcinoma

–        APML

7. Miscellaneous

–        Liver failure

–        Pulmonary embolism

–        Pancreatitis

–        Snake venom

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Category: Medical, Pathology

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