Drug-Induced Gingival Overgrowth: Definition, Etiology, Clinical features, Differential diagnosis, Treatment

October 1, 2011 | By | Reply More

Drug-Induced Gingival Overgrowth: Definition,Etiology, Clinical features, Differential diagnosis, Treatment

Definition: Drug-induced gingival overgrowth is a relatively common disorder of the gingiva due to several drugs.

Etiology: The most common drugs associated with the condition are phenytoin, ciclosporin, and calcium channel blockers.

Clinical features:

  • The gingival overgrowth is usually related to the dose of the drug, the duration of therapy, the serum concentration, and the presence of dental plaque.
  • Clinically, both marginal gingiva and interdental papillae appear enlarged and firm, with a surface that may be smooth, stippled, or lobulated, with little or no inflammation.
  • The gingival overgrowth may be localized or generalized and can partially or entirely cover the crown of the teeth.
  • In severe cases, difficulties in mastication and speech may occur.
  • The diagnosis is made on the basis of the medical history and the clinical features.
Differential diagnosis:
  • Hereditary gingival fibromatosis
  • Mouth breathing gingivitis
  • leukemia
  • Crohn disease
  • amyloidosis


  • Improvement of oral hygiene
  • gingivectomy
  • discontinuation of the offending drug

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Category: Dental, Oral Pathology

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