Epidemiological Causes of Cancer

November 9, 2012 | By | Reply More

Epidemiological Causes of Cancer

Epidemiology can help us understand the causes of cancer by examining patterns of distribution of cases by age, sex, other illnesses, social class, geography and so on. Sometimes these give strong pointers to the molecular or cellular causes of the disease, such as the association between aflatoxin production within contaminated food supplies and certain p53 gene mutations in hepatocellular carcinomas. However, for many solid cancers such as breast and colorectal, there is evidence of a multi-factorial pathogenesis, even when there is a principal environmental cause


  • Cytotoxics
  • Leukaemia


  • Schistosomiasis
  • Human papillomavirus 16 and 18
  • →Squamous bladder cancer
  • →Cervical cancer


  • Breast cancer gene 1/2
  • Hereditary non-polyposis colorectal cancer gene
  • Adenopolyposis coli gene
    • → Breast and ovarian cancer
    • → Colon and endometrial cancer
    • → Colorectal cancer


  • Western (specific cause still unclear)
  • Tobacco
  • Alcohol
  • Aflatoxin
    • Western (specific cause still unclear)
    • Tobacco
    • Alcohol
    • Aflatoxin


  • Asbestos
  • Aniline dyes
  • Ultraviolet (UV) light
    • →Mesothelioma
    • →Bladder cancer
    • Skin cancers

Category: Medicine, Pathology

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