Glomerulonephritis ppt

November 12, 2011 | By | Reply More

Glomerulonephritis ppt

glomerulonephritis ppt

PowerPoint lecture slide

Size: 2.80 MB

Download

 

 

 


 

 

Diseases commonly associated with acute GN:

  • Post streptococcal GN
  • Non- streptococcal post-infectious GN.
  • Infective endocarditis
  • Visceral abscess
  • SLE
  • Henoch-schonlein syndrome
  • cryoglobulinemia

Pathology of acute glomerulonephritis

 

Diffuse proliferative GN (PGN)

 

Ø proliferation of cells within the glomeruli, accompanied by leukocyte filtrate

 

Ø typical features of immune complex disease :

- hypocomplimentemia

- granular deposits of IgG &

complement on GBM

 

Ø  Implicated antigens seem to be endostreptosin and nephritis – plasmin- binding ptn

Light microscopy

 

image21 Glomerulonephritis ppt

 

image23 Glomerulonephritis ppt
Clinical features
  • Abrupt onset of :
  • glomerular haematuria (RBC casts or dysmorphic RBC).
  • non-nephrotic range proteinuria ( < 2 g in 24 hrs) .
  • oedema ( periorbital, sacral ).
  • hypertension.
  • transient renal impairment (oliguria, uraemia).

Investigation

 

Base line measurements:

-  ↑ Urea

-  ↑ Creatinine

- Urinalysis (MSU) :

a) Urine microscopy (red cell cast)

b) proteinuria

 

Diagnostically useful tests :

  • Culture (swab from throat or infected skin)
  • Serum anti-streptolysin-O titre
  • Hepatitis B surface antigen
  • Hepatitis C antibody
  • anti DNA , ANCA
  • ↓C3,4
  • Renal biopsy

Comlications

 

  • Nephrotic syndrome
  • HTN
  • AKI
  • Volume overload
  • Pulmonary edema
  • Chronic glomerulonephritis and CKI

Management and prognosis

 

Has a GOOD prognosis .

- Supportive measures until spontaneous recovery.

- Control HTN.

- Fluid balance.

- Oliguric with fluid overload.

- GN complicating SLE or systemic vasculitides : immunosuppression with prednisolone, cyclophosphamide or azathioprine/ MMF.

Tags: , , , , , , , , , , , ,

Category: Medical, Powerpoint

WARNING: Any unauthorised use or reproduction of  www.neuronarc.com content for commercial or any purposes is strictly prohibited and constitutes copyright infringement liable to legal action.