Haematology MCQs with Answers Part – 2

February 7, 2013 | By | Reply More

Haematology MCQs with Answers Part – 2

1. With respect to Sickle cell anaemia:

a. HbS solubility is decreased in the deoxygenated state  True  False

b. Infarctive sickle crisis causes severe pain  True  False

c. Adults with sickle cell disease typically have Howell Jolly bodies and acanthocytes in the peripheral blood  True  False

d. The disease usually presents in the first month of life True  False

e. The anaemia is due to decreased production of the abnormal globin chain  True  False


2. In untreated ß thalassaemia major (homozygous):

a. Splenomegaly is present due to the presence of extramedullary erythropoiesis  True  False

b. Haemoglobin electrophoresis most commonly shows a decrease in HbA2 True  False

c. Iron absorption from the gut is increased  True  False

d. Gene deletions are more common than point mutations in the ß globin gene  True  False

e. Intramedullary haemolysis contributes to the anaemia  True  False


3. With respect to Chronic Myeloid Leukaemia (CML):

a. the diagnostic genetic lesion is the bcr-abl fusion gene  True  False

b. untreated CML undergoes transformation to acute leukaemia  True  False

c. splenomegaly is an unusual clinical finding  True  False

d. it is characterised by maturation arrest in the neutrophils  True  False

e. the absolute count of basophils in the peripheral blood is increased True  False


4. With respect to the chronic myeloproliferative disorders:

a. mutation of the JAK 2 gene is typical of Polycythemia vera  True  False

b. patients with myelofibrosis have small, fibrotic spleens  True  False

c. patients with essential thrombocythemia may present with arterial thrombosis  True  False

d. patients with essential thrombocythemia may present with bleedin  True  False

e. patients with Polycythemia vera typically progress to acute leukaemia  True  False

5. With respect to iron metabolism:

a. The primary mechanism for control of iron stores is excretion of iron  True  False

b. Inorganic iron enters the duodenal enterocyte by means of DMT 1 (divalent metal transporter 1)  True  False

c. Synthesis of the transferrin receptor (TfR) is decreased in iron deficiency  True  False

d. Increased hepcidin levels cause impaired mobilisation (or use) of macrophage iron stores True  False

e. Compounds such as phytates e.g. in bran, prevent the absorption of inorganic iron  True  False

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