Haemolytic Anaemias:Definition & Classification

September 2, 2011 | By | Reply More

Haemolytic Anaemias:Definition & Classification

Definition: results from excessive red cell destruction. Life span of RBC may be 2-3 days in extreme case.

Classification:

INTRACORPUSCULAR OR INTRINSIC:

A. Hereditary(congenital) Haemolytic Anaemia:

  1. Abnormality in the red cell membrane e.g. hereditary spherocytosis, eliptocytosis, pyro-poikilocytosis.
  2. Deficiency in red cell enzymes e.g. G6PD deficiency, PK deficiency.
  3. Abnormality in the haemoglobin molecule:
    • Sickle cell anaemia
    • Haemoglobin C
    • Thalassaemia

B. Acquired Haemolytic Anaemia:

Paroxysmal Nocturnal Haemoglobinuria (PNH)

EXTRACORPUSCULAR OR EXTRINSIC:

A. Immunological HA:

  1. Auto-immune haemolytic  anaemia
  2. Allo-immune haemolytic  anaemia
  3. Drugs induced HA

B. Non-Immunological HA:

  1. Mechanical:
  • DIC (Disseminated Intravascular Coagulation)
  • TTP(Thrombotic Thrombocytopenic Purpura)
  •  HUS (Haemolytic Uraemic Syndrome)
  1. Drugs e.g penicillin, dapsone, methyldopa,maloprim
  2. Infections: malaria
  3. chemicals
  4. Severe burns

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Category: Medical, Pathology

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