Kaposi Sarcoma| Definition , Etiology , Clinical features, Investigation, Differential diagnosis, Treatment

September 18, 2011 | By | Reply More

Kaposi Sarcoma| Definition , Etiology , Clinical features, Investigation, Differential diagnosis, Treatment

 

Definition
•Kaposi sarcoma is a malignant neoplasm, probably of endothelial cell origin.
Etiology
•Presumably herpesvirus type 8, immunosuppression
Picture10 Kaposi Sarcoma | ppt
Classic Kaposi sarcoma of the nose.
Clinical features
•Four forms are recognized.
Classic: This is most common in Jewish and other Mediterranean individuals, and primarily involves the skin and rarely the oral mucosa, usually in men over 60 years of age.
African (endemic): This primarily involves the skin and lymph nodes, and rarely the oral mucosa.
Immunosuppression-associated(iatrogenic) : This occurs in recipients of organ transplants, and may have an aggressive course. The oral mucosa is rarely affected.
AIDS-related(epid emic): This has a high incidence among AIDS patients, and primarily involves the skin, lymph nodes, viscera, and frequently the oral mucosa.
•The skin lesions appear as multiple or solitary macules, nodules, or tumors with deep red or dark blue color (Fig. ). The feet, hands, nose, and ears are the most common sites of involvement.
•Clinically, the oral lesions present as multiple or solitary red or brownish- red patches or elevated plaques or tumors . The palate and gingiva are the most common sites affected, followed by buccal mucosa, tongue, and lips.
Laboratory tests
•Histopathological examination.
Differential diagnosis
•Pyogenic granuloma,
•peripheral giant-cell
•granuloma,
•bacillary angiomatosis,
•hemangioma,
•angiosarcomas.
•Interferon, chemotherapy, radiotherapy, or surgical excision in small, localized lesions.

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Category: Dental, Oral Pathology, Oral Surgery

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