Langerhans Cell Histiocytosis : Clinical features

November 12, 2011 | By | Reply More

Langerhans Cell Histiocytosis: Clinical features

Clinical features
  • Oral lesions may occur in all four forms but are more common in the first three forms.
  • Eosinophilic granuloma is usually localized and appears as solitary or multiple ulceration on the gingiva and the palate usually associated with bone destruction and tooth loosening or loss .
  • Hand–Schüller–Christian disease and Letterer– Siwe disease are disseminated forms and appear with multiple oral ulcerations, ecchymosis, edema, gingivitis and periodontitis, jaw bone involvement, and tooth loss.
  • Skin rash, otitis media, lung, liver, bone and lymph nodes are commonly involved.
  • The classic triad of Hand–Schüller–Christian consists of bone lesions, diabetes insipidus, and exophthalmos.
  • The clinical diagnosis should be confirmed by laboratorytests.


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Category: Dental, Oral Pathology

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