Langerhans Cell Histiocytosis: Clinical features
- Oral lesions may occur in all four forms but are more common in the first three forms.
- Eosinophilic granuloma is usually localized and appears as solitary or multiple ulceration on the gingiva and the palate usually associated with bone destruction and tooth loosening or loss .
- Hand–Schüller–Christian disease and Letterer– Siwe disease are disseminated forms and appear with multiple oral ulcerations, ecchymosis, edema, gingivitis and periodontitis, jaw bone involvement, and tooth loss.
- Skin rash, otitis media, lung, liver, bone and lymph nodes are commonly involved.
- The classic triad of Hand–Schüller–Christian consists of bone lesions, diabetes insipidus, and exophthalmos.
- The clinical diagnosis should be confirmed by laboratorytests.