Malignant Granuloma| Definition , Etiology , Clinical features, Investigation, Differential diagnosis, Treatment

September 18, 2011 | By | Reply More

Malignant Granuloma| Definition , Etiology , Clinical features, Investigation, Differential diagnosis, Treatment

Definition
•Malignant granuloma, lethal midline granuloma, and nasal natural killer T-cell lymphoma represent a disease spectrum characterized by progressing ulcerations and necrosis that characteristically involves the midline structures of the palate and nasal cavity.
Etiology
•Unclear, although Epstein–Barr virus is frequently associated with the disease.
Picture8 Malignant Granuloma | ppt
Malignant granuloma: nonhealing ulcer and necrosis on the palate.
Clinical features
•Three varieties of the disease have been recognized: inflammatory or idiopathic; neoplastic or polymorphic reticulosis; and lymphoma with high-grade malignancy.
•Clinically, the condition is characterized by prodromal signs and symptoms (epistaxis, pain, nasal stuffiness and obstruction with a purulent discharge, foul-smelling secretions), and nonhealing ulceration and necrosis, usually of the nasal cavity and palate) (Fig.).
•The ulcers deteriorate rapidly, causing destruction and perforation of soft and hard tissues, finally resulting in severe disfigurement (Fig.).
•The prognosis is poor.
Laboratory tests
•Histopathological examination.
Differential diagnosis
•Wegener granulomatosis,
•systemic mycoses,
•non-Hodgkin lymphoma,
•malignancies,
•tuberculosis,
•necrotizing sialadenometaplasia.
•Radiotherapy, chemotherapy.

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Category: Dental, Oral Pathology, Oral Surgery

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