Nephrotic Syndrome (NS) – Definition, Type, Pathogenesis
NS is an accumulation of symptoms and signs and is characterized by proteinuria, hypoproteinemia, edema, and hyperlipidemia.
1.Clinical type – Simple NS ; Nephritic NS
Minimal change disease, MCD: 80% of patients
The primary disorder is an increase in glomerular permea- bility to plasma proteins.
▲Foot processes of the visceral epithelium of the GBM.
2.The loss of the negative charges on the GBM.