Nephrotic Syndrome (NS) – Definition, Type, Pathogenesis

September 4, 2011 | By | Reply More

Nephrotic  Syndrome (NS) – Definition, Type, Pathogenesis

Definition
NS is an accumulation of   symptoms and signs and is characterized by proteinuria, hypoproteinemia,  edema, and   hyperlipidemia.

 

Type
1.Clinical type – Simple NS ; Nephritic NS
2.Response to steroid therapy
3. Pathologic type (P328)
Minimal change disease,  MCD: 80% of patients

 

Pathogenesis
The primary disorder is an increase in glomerular permea- bility to plasma proteins.
▲Foot processes of the visceral epithelium of the GBM.

 

1.The construction of the glomerular basement memb-rane has changed.
2.The loss of the negative  charges on the GBM.

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Category: Medical, Medicine

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