Nephrotic Syndrome (NS) – Definition, Type, Pathogenesis
Nephrotic Syndrome (NS) – Definition, Type, Pathogenesis
Definition
NS is an accumulation of symptoms and signs and is characterized by proteinuria, hypoproteinemia, edema, and hyperlipidemia.
NS is an accumulation of symptoms and signs and is characterized by proteinuria, hypoproteinemia, edema, and hyperlipidemia.
Type
1.Clinical type – Simple NS ; Nephritic NS
1.Clinical type – Simple NS ; Nephritic NS
2.Response to steroid therapy
3. Pathologic type (P328)
Minimal change disease, MCD: 80% of patients
Minimal change disease, MCD: 80% of patients
Pathogenesis
The primary disorder is an increase in glomerular permea- bility to plasma proteins.
▲Foot processes of the visceral epithelium of the GBM.
The primary disorder is an increase in glomerular permea- bility to plasma proteins.
▲Foot processes of the visceral epithelium of the GBM.
1.The construction of the glomerular basement memb-rane has changed.
2.The loss of the negative charges on the GBM.
2.The loss of the negative charges on the GBM.
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