Oral Submucous Fibrosis Etiology, Histopathology ,Treatment

April 22, 2012 | By | Reply More

Oral Submucous Fibrosis Etiology, Histopathology ,Treatment

Oral submucous fibrosis (or OSMF) is a chronic,complex,irreversible,highly potent pre-cancerous condition characterized by juxta-epithelial inflammatory reaction and progressive fibrosis of the submucosal tissues (lamina propria and deeper connective tissues).

Definition : Oral Submucous Fibrosis ( OSMF ) is a pre-cancerous condition. It occurs below the mucous membrane. Fibrosis occurs in sub-mucous (CT) layer.

1. Indian subcontinent (IndiaBangladeshSri LankaPakistan)
2. Part of China and Taiwan
3. Nil in Europe but occurs in migrating people from the sub-continent

1. Betel quid
2. Areca nut
3. Tobacco
4. Alcohol consumption
5. Reverse smoking

1. The mucous membrane layer and muscular layer will be atrophied.
2. The sub-mucous layer is avascular; so high glazy appearance.

1. Withdrawal of causative factors

2. Medications:

  • a. Corticosteroid: Dexamethasone either topical or injection form within the lesion. Hyaluronidaze enzyme is given with the Dexamethasone
  • b. Antitoxidant
  • c. Vasodilators

3. Surgical:

  • a. The band should be removed by surgical excision but it causes more scars.
  • b. Split thickness skin graft may be done
  • c. Temporalis muscle myotomy
  • d. Coronoidectomy

4. Physiotherapy: Muscle stressing exercise if patient can not open the mouth.

5. Follow-up in every month depending upon the surgeon. The condition must be followed to observe any cancerous change.

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Category: Dental, Oral Medicine, Oral Pathology, Oral Surgery

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