Stevens–Johnson Syndrome: Definition, Etiology, Clinical features, Differential diagnosis,Treatment
Definition ;Stevens–Johnson syndrome, or erythema multiforme major, is a severe form of erythema multiforme that predominantly affects the mucous membranes.
Etiology: Drugs usually trigger the disease.
- The oral lesions are always present, and are characterized by extensive vesicle formation, followed by painful erosions covered by grayish-white or hemorrhagic pseudomembranous .
- The lesions may extend to the pharynx, larynx, and esophagus.
- The ocular lesions consist of conjunctivitis, uveitis, symblepharon, or even panophthalmitis.
- The genital lesions are balanitis or vulvovaginitis, and scrotal erosions.
- The skin manifestations may vary from very light to severe.
- The diagnosis is mainly made on the basis of the clinical presentation.
- Behçet disease,
- primary herpes simplex.