Stevens–Johnson Syndrome: Definition, Etiology, Clinical features, Differential diagnosis,Treatment

September 20, 2011 | By | Reply More

StevensJohnson Syndrome: Definition, Etiology, Clinical features, Differential diagnosis,Treatment

Definition ;Stevens–Johnson syndrome, or erythema multiforme major, is a severe form of erythema multiforme that predominantly affects the mucous membranes.

Etiology: Drugs usually trigger the disease.

Clinical features:

  • The oral lesions are always present, and are characterized by extensive vesicle formation, followed by painful erosions covered by grayish-white or hemorrhagic pseudomembranous .
  • The lesions may extend to the pharynx, larynx, and esophagus.
  • The ocular lesions consist of conjunctivitis, uveitis, symblepharon, or even panophthalmitis.
  • The genital lesions are balanitis or vulvovaginitis, and scrotal erosions.
  • The skin manifestations may vary from very light to severe.
  • The diagnosis is mainly made on the basis of the clinical presentation.

Differential diagnosis;

  • Behçet disease,
  • pemphigus,
  •  pemphigoid,
  • primary herpes simplex.

Treatment : Systemic steroids; antibiotics, if considered necessary in severe cases.

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Category: Dental, Oral Medicine, Oral Pathology

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