Tag: Pemphigus Vulgaris

Pemphigus Vulgaris: Clinical features, Pathology, Differential diagnosis, Treatment

Pemphigus Vulgaris: Clinical features, Pathology, Differential diagnosis, Treatment

Pemphigus Vulgaris Pemphigus vulgaris is a severe chronic bullous B-cell-mediated autoimmune disease in which autoantibodies develop into antigens within the desmosome-tonofilament junction of the intercellular bridges. Such autoantibodies fix complement and initiate inflammation, which causes a suprabasilar split (intraepithelial blister) as the primary pathogenesis. Etiology Autoimmunity. Desmoglein 1 and 3 are the main target antigens. […]

November 30, 2012 | By | Reply More
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