Wegener Granulomatosis- Definition, Etiology, Clinical features, Diagnosis, D/D, Rx of Wegener Granulomatosis

September 12, 2011 | By | Reply More

Wegener Granulomatosis- Definition, Etiology, Clinical features, Diagnosis, D/D, Rx of Wegener Granulomatosis

Definition and etiology : Wegener granulomatosis is a rare chronic granulomatous disease with a probably immunological pathogenesis.

Clinical features:

  • The disease is characterized by necrotizing granulomatous lesions of the respiratory tract, generalized focal necrotizing vasculitis, and necrotizing glomerulitis.
  • The oral lesions are fairly common and present clinically as solitary or multiple irregular ulcers, surrounded by an inflammatory zone.
  • The tongue, palate, buccal mucosa, and gingiva are the most commonly affected areas.

Laboratory tests:  Histopathological examination, detection of antineutrophil cytoplasmantibodies (ANCA) in the serum.

Differential diagnosis:

  • Malignant granuloma,
  • tuberculosis,
  • non-Hodgkin lymphoma,
  • leukemia,
  • systemic mycoses,
  • squamous-cell carcinoma.

Treatment : A combined regimen with

  • steroids,
  • azathioprine and
  • cyclophosphamide.

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Category: Dental, Oral Pathology

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